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apalutamide will minimize the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in decrease exposure to these remedies.Doses may very well be enhanced little by little as essenti